A dendritic nexus in the circuits that coordinate learning
When we learn a complex behavior the nervous system must continuously drive new actions, compare predictions for the actions against outcomes, and strengthen or weaken the connections between neurons (synapses) in order to improve future actions. Recent theories of learning suggest that spikes generated in the apical dendrites of cortical neurons may play a key role in motor learning. We are currently using advanced optical techniques to both monitor and manipulate activity in the dendrites of a subset of neurons in the frontal cortex that have a well-delineated role in action planning.
- Current Funding: NINDS 5R01NS127902-02
- Previous Funding: Whitehall Foundation Grant for Control of Motor Learning by Dendritic Computations Project
Imaging at the speed of spikes: An electro-optical multiphoton microscope
Signals in the brain are transmitted and transformed on a millisecond timescale. The precise timing of activity can carry unique information, correlate perceptual decisions, and powerfully influence synaptic plasticity. Therefore, to understand the circuits that generate behavior and the circuit changes responsible for learning, we have developed an entirely new electro-optical system capable of deflecting larger laser beams at high speeds. We are using these new deflectors to develop a 2P microscope capable of random-access multiphoton interrogation of neurons and synapses with sub-microsecond access times.
- Current Funding: BRAIN Initiative 1RF1NS128658-01
- Previous Funding: Wallin Neuroscience Discovery Award
